Pal-GHK (Palmitoyl Tripeptide-1) 200mg – Research Grade

Look, if you’re researching skin repair and collagen synthesis, you need the right tool for the job. This is Pal-GHK. It’s not magic dust; it’s a purpose-built synthetic peptide where a palmitoyl fatty acid is bonded to the Gly-His-Lys (GHK) amino acid sequence. The “Pal” part isn’t just for show—it’s believed to help the molecule penetrate the stratum corneum effectively to get where it needs to go for in-vitro study.

The GHK sequence itself is a key signal. Research indicates it’s a fragment found in type I collagen. Think of it like a distress signal released at a damage site, specifically calling in fibroblasts. These are the cells responsible for building the skin’s support structure: collagen, elastin, and glycosaminoglycans. If your lab work involves the extracellular matrix, this is a core compound to have on the bench.

What the Data Points To

We deal in research, not hype. Here’s what published studies suggest Pal-GHK may influence, based on controlled experiments:

• Skin Thickness & Collagen: A placebo-controlled trial noted a statistically significant ~4% increase in skin thickness after exposure. Other clinical data points to the GHK sequence enhancing collagen production in dermal fibroblasts and stimulating keratinocyte proliferation.
• Antioxidant & Protective Actions: Biological data suggests interaction with antioxidant-related genes. Studies propose it may have protective effects against oxidative stress from factors like UV radiation, potentially countering reactive carbonyl species (RCS) that can lead to protein glycation.
• Wound Repair Metrics: Lab studies on ulcer models are compelling. One reported enhanced wound closure and a significantly lower incidence of infection (7% vs. 34% in vehicle group). Another found the time for wounds to fill with granulation tissue dropped from 25 days to 14 days with GHK. Histological assessments suggested promoted neovascularization and a modulated inflammatory response.
• Skin Appearance Factors: Research suggests correlations with improved skin hydration, moisture retention, and a smoothing effect. Studies in animal models have also explored its influence on reducing redness and discoloration following photodamage.

Specifications

Sequence:	Palmitoyl-Gly-His-Lys
Molecular Formula:	C30H54N6O5
Molecular Weight:	578.8 g/mol
Purity:	>99% (HPLC verified – see COA)
Synonyms:	Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide