N-Acetyl Semax (25mg) – Research Grade

Price: $62.70

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Here’s the straight talk on N-Acetyl Semax. Think of it as an upgraded version of the classic Semax peptide. The core is the same 4-amino acid chain (Met-Glu-His-Phe) found in ACTH. The key difference is the addition of two elements: an acetyl group at the N-terminus and a Pro-Gly-Pro (PGP) fragment at the C-terminus.

This isn’t just cosmetic. The acetylation is believed to help the peptide resist breakdown by enzymes, potentially extending its active life in research models. The real engineering, though, is in that PGP tail. Early data suggests this modification increases the peptide’s lipophilicity—its ability to dissolve in fats. Why does that matter? The blood-brain barrier (BBB) is notoriously selective, built to keep most things out. The increased lipophilicity from the PGP fragment may improve the peptide’s passive diffusion across that barrier or facilitate uptake via specific cellular transport pathways. In simpler terms, the modification is designed to help more of the compound get to where researchers want to study it: the central nervous system.

Research Context & Potential Applications

Formal studies on N-Acetyl Semax itself are limited, so the scientific community often looks to research on its predecessor, Semax, to inform hypotheses. The proposed enhancements in stability and BBB permeability make N-Acetyl Semax a point of interest for several research avenues.

• Cognitive Function Studies: Semax research has shown notable impacts in models of memory and attention. In one trial, subjects demonstrated a 71% aptitude in memory recall tasks versus 41% in controls. fMRI data also indicated increased activation in key brain networks. The theoretical improved bioavailability of the N-Acetyl form makes it a compelling candidate for further investigation in this area.
• Neurotrophic Factor Modulation: A primary mechanism studied with Semax is its interaction with Brain-Derived Neurotrophic Factor (BDNF). Research suggests it may elevate BDNF levels and activate its primary receptor, trkB, in specific brain regions like the hippocampus. This pathway is crucial for neuronal health, survival, and plasticity.
• Neuroprotection & System-Specific Research: Studies on Semax indicate potential protective effects in models of ischemic stroke, with observed correlations between BDNF increase and functional recovery. Other research points to possible interactions with systems involving serotonin, enkephalins, and proteins related to inflammation and cell death (like JNK and CREB), suggesting a complex regulatory role.

Specifications

• Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2
• Molecular Formula: C37H51N9O10S
• Molecular Weight: 858.97 g/mol
• Purity: >99% (HPLC verified)